A new method of creating constitutive model of masonry is reported in this work. The model is not an explicit orthotropic elastic-plastic one, but with an artificial neural network (ANN) giving an implicit constitutive function. It relates the new state of generalised stresses Σ n+1 with the old state Σ n and with an increment of generalised strains ΔE (plane-stress conditions are assumed). The first step is to run a strain- controlled homogenisation, repeatedly, on a three-dimensional finite element model of a periodic cell, with elastic-plastic models (Drucker–Prager) of the components; thus a set of paths is created in (Σ, ΔE) space. From these paths, a set of patterns is formed to train the ANN. A description of how to prepare these data and a discussion on ANN training issues are presented. Finally, the procedure based on trained ANN is put into a finite-element code as a constitutive function. This enables the analysis of arbitrarily large masonry systems. The approach is verified by comparing the results of the developed model basing on ANN with a direct (single-scale) one, which showed acceptable accuracy.