In this study, the effects of replacing fine aggregate by granulated lead/zinc slag waste (GLZSW) on the thickness of concrete shields against X-ray radiation and on the compressive strength of concrete have been investigated. The fine aggregate was substituted by GLZSW in four percentages: 25%, 50%, 75%, and 100% (by weight). The first aim of the present study was to compare the thicknesses of concretes with GLZSW and control concrete using Lead Equivalent (LE). The second aim was to assess the effects of replacing fine aggregate by GLZSW on the compressive strength of concrete. Results of this study indicated that the compressive strength of mixed concretes increased significantly compared to the control upon replacing fine aggregate by GLZSW; the mixture containing 100% GLZSW had the greatest compressive strength. Further, the inclusion of GLZSW as a substitute for fine aggregate increased the radiation attenuation properties and consequently decreased the thickness of concrete shields in direct proportion to the mixing ratio of GLZSW. The results revealed that concrete mixes containing 100% GLZSW offered the greatest reduction in shield thickness. The study shows that there is a promising future for the use of GLZSW as substitute for fine aggregate in concrete used to shield against X-ray radiation.