This paper presents the results of a study investigating the influence of non-clinker constituents in cement on the risk of deleterious alkali-silica reaction (ASR). The cements selected for this study were CEM II types containing commonly used non-clinker constituents, such as ground granulated blast furnace slag (GGBS) and silica fly ash. Additionally, a binder was prepared by mixing CEM I cement with metahalloysite in a 3:1 ratio. As a reference, CEM I cements without non-clinker constituents were used. Expansion tests were conducted on mortars using standard reactive aggregate (borosilicate glass cullet) according to ASTM C 441. The results, evaluated against the criteria outlined in ASTM C 1157, demonstrated that the binders with non-clinker constituents met the “Option-R” requirement. The expansion of, mortars made with cements containing non-clinker constituents was significantly reduced compared to mortars made with pure Portland cement. The most significant effectiveness in this regard was achieved with the metahalloysite cement. The obtained expansion results correlated well with the microstructural changes in the mortars, which can be linked to the occurrence of ASR. The microstructure of the mortars was examined using scanning electron microscopy..