With the development of the society in recent years, there are more and more housing construction areas. The traditional concrete has not been able to satisfy the demand of housing construction. In this study, prefabricated concrete was applied in the design of assembling style houses considering their characteristics, and its economic, environmental and social benefits were analyzed combining risk matrix evaluation method and management strategy. It was found that the use of prefabricated concrete as a building material could effectively shorten the construction period, reduce the construction cost and improve the construction safety, playing a role of energy saving and environmental protection. Therefore it was concluded that prefabricated concrete can improve the efficiency of construction, reduce environmental pollution and save energy. This work provides a reference for the application of prefabricated concrete in residential buildings and its safety management.