The liquidation of underground mines by the flooding leads to movements of the rock mass and land surface as a result of pressure changes in the flooded zones. The changes resulting from the rising water table caused by the changes in the stress and strain state, as well as the physical and mechanical properties of rock layers, can lead to damage to building structures and environmental changes, such as chemical pollution of the surface water. For this reason, the ability to predict the movements of rock masses generated as a result of mine closure by flooding serves a key function in relation to the protection of the land surface and buildings present thereon. This paper presents an analysis of a steel industrial portal-frame structure under loading generated by the liquidation of a mine by flooding. The authors obtained land surface uplift results for the liquidated mine and used them in a numerical simulation for the example building. Calculations were performed for different cases, and the results were compared to determine whether limit states may be exceeded. A comparison was made between the cases for the design state and for additional loading caused by the uplift of the subsurface layer of the rock mass.