This paper conducts research based on the hollow slab members in the reconstruction and expansion project of expressways, two types of numerical finite element models with and without considering bond-slip relationship of reinforcement and concrete are established, and verified by tests. The distribution characteristics of crack spacing in reinforced concrete beams are studied. The results show that the bond-slip characteristics of reinforced concrete have little effect on the load-deflection characteristics of 8m hollow slab beam. Due to the influence of the bond-slip relationship of reinforced concrete, the load-deflection curve is partially serrated, while without considering the bond-slip relationship of reinforced concrete, the load-deflection curve is smooth. In the numerical model without considering the bond-slip characteristics, almost all damage occurs in the longitudinal direction, and the distribution characteristics of cracks can’t be accurately determined. Regardless of whether the bond-slip is considered or not, the macroscopic characteristics of the stress distribution is: smaller near the support and larger at the mid-span. As secondary flexural cracks expand, models with and without consideration of bond-slip characteristics can’t calculate crack spacing based on the stress distribution characteristics of the reinforcement.