The aim of the study is to compare flexible pavement design lifespans and the main factors which create their values for a standard structure and one with an anti-fatigue course AF at different parameter values of pavement and its load, relevant to their design processes. Depending on the mixture used for the anti-fatigue course or the course thickness, durability improvement of the pavement (compared to the durability of a standard structure) can be obtained by extending the design lifespan of the asphalt base course or by extending the design lifespan of the AF course. On sections with predominantly slow traffic, the lifespan decreases significantly compared to sections with typical vehicle speed – the relative decrease is greater if anti-fatigue course is applied.