This paper investigates the influence of isolation systems on the seismic behavior of urban reinforce concrete bridge. The performance of the Hesarak Bridge constructed in Karaj city, Iran with two isolation systems; i.e. the existing elastomeric rubber bearing (ERB) and a proposed lead rubber bearing (LRB) is discussed. The numerical model was implemented in the well-known FEM software CSIBridge. The isolated bridge has been analyzed using nonlinear time history analysis method with seven pairs of earthquake records and the results are compared for the two isolation systems. The LRB isolators are shown to have superior seismic performance in comparison with the existing ERB systems based on the response evaluation including force on the isolator, pier base shear, deck acceleration, bending moment, pier displacement, and energy dissipation.