Construction workers consistently prioritise safety when carrying out their tasks on construction sites. The matter of ensuring labour safety on construction sites requires attention, investment, and strict adherence to regulations from the outset. This is crucial due to the numerous potential risks inherent in the construction industry. In the current market economy, many entities have shown a lack of focus on safety in favour of profit. This article examines the factors influencing labour safety during the construction process on sites in the Mekong Delta region. It employs a survey to gather insights from experts and managers in the area, followed by the application of SPSS software to quantitatively assess the impact of these factors on labour safety in the region's construction sites. The analysis results provide a foundation for relevant units to suggest solutions aimed at minimising occupational accidents and enhancing awareness among participants at construction sites across the country, with a specific focus on the Mekong Delta region. This initiative ultimately aims to ensure that workers at construction sites enjoy a comfortable and safe working environment, while also mitigating financial losses to the national budget and fostering a secure workplace for all workers.