In this paper, four full-scale concrete columns with high-strength spiral stirrups (HSSS) are constructed and tested under low-cycle repeated loading. The specimens consisted of two castin- place columns and two precast concrete columns encased by a partly square steel pipe and bolt bars.The structural analysis of the HSSS columns of precast concrete conducted here is novel, and past experimental data for this are not available.To assess the seismic behavior and failure mechanisms of the new connections, quasi-static tests were carried out on columns prefabricated with them and cast-in-place specimens.The responses of all columns were compared, and the results showed that the failure modes of all columns are the large eccentric damage, and the destruction of all specimens occur at the column foot. The anti-seismic property of the precast HSSS concrete columns was comparable to that of the HSSS cast-in-place columns. A comparison of such performance parameters as energy dissipation and coefficient of ductility revealed that the precast HSSS concrete columns are suitable for use in earthquake zones.