In the paper there the laboratory tests of interaction between thin-walled beams of the Z crosssection and the sandwich panels with PIR foam core are presented. The different numbers of connectors (0, 4, and 8) were used to connect the sandwich panels with the thin-walled beams. Furthermore, the parallel and perpendicular to the longitudinal axis of the thin-walled beam load arrangement was analysed. The research provides a qualitative and quantitative comparison of the mentioned experiments using the ultimate capacity, the deformation capacity, and the stiffness. In the second part of the paper, the numerical analysis of the thin-walled beam was also performed. The beam was modelled as a shell element and loaded in two ways, which corresponded to the loading scenario during laboratory tests (uniformly distributed and concentrated loads). The results of the numerical calculations of the beam without lateral stabilization were compared with the laboratory results of the beam stabilized by the sandwich panels.