To study the difference in seismic vulnerability of multiple typical structures in multiple intensity zones, the seismic damage of 7099 buildings of Dujiangyan masonry structure (MS), reinforced concrete structure (RC) and bottom frame seismic wall masonry (BFM) in the 2008 Wenchuan earthquake in China is summarized and analysed. First, a statistical analysis of the data is carried out, the empirical seismic vulnerability matrix and model curves are established by considering the number of storeys, the age and the fortification factors.The vulnerability curves of the cumulative exceeding probability of the empirical seismic damage and the grade of the seismic damage in multiple intensity zones are shown. The mean damage index vulnerability matrix model is proposed and verified using the empirical seismic damage matrix of typical structures.